Human Epidermal growth factor Receptor 2 (HER2) is also called ERBB2, HER2,HER2 /neu, NEU, NGL,TKR1 and cerb B2,and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2 is a cell membrane surfacebound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. HER2 is thought to be an orphan receptor, with none of the EGF family of ligands able to activate it. Approximately 30% of breast cancers have an amplification of the HER2 gene or overexpression of its protein product. Overexpression of this receptor in breast cancer is associated with increased disease recurrence and worse prognosis. HER2 appears to play roles in development, cancer, communication at the neuromuscular junction and regulation of cell growth and differentiation . - Proteine/Peptide
Immobilized Trastuzumab at 0.5 µg/mL (100 µL/well) can bind FITC-Labeled Human Her2, His Tag (Cat. No. HE2-HF224) with a linear range of 0.02-0.313 µg/mL (QC tested).
HE2-HF224-25ug
FITC-Labeled Human Her2, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
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