Human IGF-I Protein, His Tag (SPR verified), Unconjugated

Product Overview

• Article Name: Human IGF-I Protein, His Tag (SPR verified), Unconjugated
• Biozol Catalog Number: ABS-IG1-H5245-1MG
• Supplier Catalog Number: IG1-H5245-1mg
• Alternative Catalog Number: ABS-IG1-H5245-1MG
• Manufacturer: AcroBiosystems
• Host: Human
• Category: Proteine/Peptide
• Species Reactivity: Human
• Conjugation: Unconjugated

Product Description

Insulinlike growth factor 1 (IGF1) is also known as somatomedin C, IGF1A, IGFI, sulfation factor, and is a hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults. A synthetic analog of IGF1, mecasermin is used for the treatment of growth failure. IGF1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges. IGF1 has a molecular weight of 7649 daltons. IGF1 is produced primarily by the liver as an endocrine hormone as well as in target tissues in a paracrine/autocrine fashion. IGF1 binds to at least two cell surface receptors: the Insulinlike growth factor 1 receptor, abbreviated as IGF1R, and the insulin receptor. The IGF1 receptor seems to be the physiologic receptor it binds IGF1 at significantly higher affinity than the IGF1 that is bound to the insulin receptor. Like the insulin receptor, the IGF1 receptor is a receptor tyrosine kinase meaning it signals by causing the addition of a phosphate molecule on particular tyrosines. Its primary action is mediated by binding to its specific receptor IGF1R, present on many cell types in many tissues. Binding to the IGF1R, a receptor tyrosine kinase, initiates intracellular signaling, IGF1 is one of the most potent natural activators of the AKT signaling pathway, a stimulator of cell growth and proliferation, and a potent inhibitor of programmed cell death. Insulinlike growth factor 1 has been shown to bind and interact with all the IGF1 Binding Proteins (IGFBPs), of which there are six (IGFBP16). Specific references are provided for interactions with IGFBP3, IGFBP4 and IGFBP7. - Proteine/Peptide

Product Properties

• Molecular Weight: 9.5 kDa
• Tag: N-10*His
• NCBI: 05019
• Buffer: PBS, pH7.4
• Purity: 90%
• Form: Powder
• Target: IGF-I

Images

Immobilized Human IGF-I R, Fc Tag (Cat. No. IGR-H5253) at 10 µg/mL (100 µL/well) can bind Human IGF-I Protein, His Tag (Cat. No. IG1-H5245) with a linear range of 0.078-5 µg/mL (Routinely tested).

Human IGF-I Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

IG1-H5245-1mg