Human IGF-I Protein, Fc Tag (MALS verified), Unconjugated

Product Overview

• Article Name: Human IGF-I Protein, Fc Tag (MALS verified), Unconjugated
• Biozol Catalog Number: ABS-IG1-H5263-1MG
• Supplier Catalog Number: IG1-H5263-1mg
• Alternative Catalog Number: ABS-IG1-H5263-1MG
• Manufacturer: AcroBiosystems
• Host: Human
• Category: Proteine/Peptide
• Species Reactivity: Human
• Conjugation: Unconjugated

Product Description

Insulinlike growth factor 1 (IGF1 or IGFI), also known as somatomedin C, is the dominant effector of growth hormone and is structurally homologous to proinsulin. Human IGF1 is synthesized as two precursor isoforms with N and alternate C-terminal propeptides (1). These isoforms are differentially expressed by various tissues (1). The 7.6 kDa mature IGF-1 is identical between isoforms and is generated by proteolytic removal of the N and C-terminal regions. Mature human IGF1 shares 94% and 96% aa sequence identity with mouse and rat IGF1, respectively (2), and exhibits crossspecies activity. It shares 64% aa sequence identity with mature human IGF2. Circulating IGF1 is produced by hepatocytes, while local IGF1 is produced by many other tissues in which it has paracrine effects (1). IGF1 induces the proliferation, migration, and differentiation of a wide variety of cell types during development and postnatally (3). IGF1 regulates glucose and fatty acid metabolism, steroid hormone activity, and cartilage and bone metabolism (4-7). It plays an important role in muscle regeneration and tumor progression (1, 8). IGF1 binds IGF1R, IGF2R, and the insulin receptor, although its effects are mediated primarily by IGF1R (9). IGF1 association with IGF binding proteins increases its plasma half-life and modulates its interactions with receptors (10). - Proteine/Peptide

Product Properties

• Molecular Weight: 34.1 kDa
• Tag: N-Fc
• NCBI: 05019
• Buffer: PBS, pH7.4
• Purity: 90%
• Form: Powder
• Target: IGF-I

Images

Immobilized Human IGF-I Protein, Fc Tag (Cat. No. IG1-H5263) at 5 µg/mL (100 µL/well) can bind Biotinylated Human IGFBP-4 Protein, His,Avitag (Cat. No. IG4-H82E3) with a linear range of 0.005-0.078 µg/mL (QC tested).

Immobilized Human IGFBP-3, His Tag (Cat. No. IG3-H52H9) at 5 µg/mL (100 µL/well) can bind Human IGF-I Protein, Fc Tag (Cat. No. IG1-H5263) with a linear range of 0.3-5 ng/mL (Routinely tested).

Human IGF-I Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.