Insulinlike growth factorbinding protein 3 is also known as IGFBP3, is a protein that, in humans, is encoded by the IGFBP3 gene. IGFBP3 forms a ternary complex of about 140 ~150 kDa with IGF1 or IGF2 and a glycoprotein insulinlike growth factor acidlabile subunit (ALS), thus alter the interaction of IGFs with their cell surface receptors. IGFBP3 exerts either proapoptotic or growth stimulatory effects depending upon the cellular context. Studies have shown that IGFBP3 can leads to the induction of apoptosis dependent or independent of the IGFIGF receptor axis, accordingly acts as a negative regulator of tumorigenesis and progressing in certain carcinomas. The highest expression level is found in the nonparanchymal cells of the liver. Expression levels are also higher during extrauterine life and peak during puberty. - Proteine/Peptide
Immobilized Biotinylated Human IGF-II, Avitag,Fc Tag (Cat. No. IG2-H82F9) at 2 µg/mL (100 µL/well) on streptavidin (Cat. No. STN-N5116) precoated (1 µg/well) plate can bind Human IGFBP-3, His Tag (Cat. No. IG3-H52H9) with a linear range of 0.01-0.313 µg/mL (QC tested).
Immobilized Human IGFBP-3, His Tag (Cat. No. IG3-H52H9) at 5 µg/mL (100 µL/well) can bind Human IGF-I, Fc Tag with a linear range of 0.6-39 ng/mL (Routinely tested).
Human IGFBP-3, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
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