Human IGF-I R / IGF-1 R Protein, Fc Tag, Unconjugated

Product Overview

• Article Name: Human IGF-I R / IGF-1 R Protein, Fc Tag, Unconjugated
• Biozol Catalog Number: ABS-IGR-H5253-1MG
• Supplier Catalog Number: IGR-H5253-1mg
• Alternative Catalog Number: ABS-IGR-H5253-1MG
• Manufacturer: AcroBiosystems
• Host: Human
• Category: Proteine/Peptide
• Species Reactivity: Human
• Conjugation: Unconjugated

Product Description

The Insulinlike Growth Factor 1 Receptor (IGF1) is also known as CD221, JTK13. and is a transmembrane receptor that is activated by IGF1 and by the related growth factor IGF2. It belongs to the large class of tyrosine kinase receptors. This receptor mediates the effects of IGF1, which is a polypeptide protein hormone similar in molecular structure to insulin. IGF1R is make up of two alpha subunits and two beta subunits ,the Both the alpha and beta subunits are synthesized from a single mRNA precursor. The precursor is then glycosylated, proteolytically cleaved, and crosslinked by cysteine bonds to form a functional transmembrane alphabeta chain.The alpha chains are located extracellularly while the beta subunit spans the membrane and are responsible for intracellular signal transduction upon ligand stimulation. IGF1R have a binding site for ATP, which is used to provide the phosphates for autophosphorylation. There is a 60% homology between IGF1R and the insulin receptor. In response to ligand binding, the alpha chains induce the tyrosine autophosphorylation of the beta chains. This event triggers a cascade of intracellular signaling that, while somewhat cell type specific, often promotes cell survival and cell proliferation. - Proteine/Peptide

Product Properties

• Molecular Weight: 129.3 kDa
• Tag: C-Fc
• NCBI: 08069
• Buffer: PBS, pH7.4
• Purity: 95%
• Form: Powder
• Target: IGF-I R / IGF-1 R

Images

Immobilized Human IGF-I R, Fc Tag (Cat. No. IGR-H5253) at 5 µg/mL (100 µL/well) can bind Biotinylated Human IGF-I, Avitag,Fc Tag (Cat. No. IG1-H82F7) with a linear range of 0.01-0.625 µg/mL (QC tested).

Immobilized Human IGF-I R, Fc Tag (Cat. No. IGR-H5253) at 5 µg/mL (100 µL/well) can bind Biotinylated Human IGF-I, His,Avitag (Cat. No. IG1-H82Q6) with a linear range of 10-78 ng/mL (Routinely tested).

Human IGF-I R, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.