Biotinylated Human IGF-I R / IGF-1 R Protein, His,Avitag(TM) (MALS verified)
Biozol Catalog Number:
ABS-IGR-H83E3-25UG
Supplier Catalog Number:
IGR-H83E3-25ug
Alternative Catalog Number:
ABS-IGR-H83E3-25UG
Manufacturer:
AcroBiosystems
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Biotin
The Insulinlike Growth Factor 1 Receptor (IGF1R) is also known as CD221 and JTK13, and is a transmembrane receptor that is activated by IGF1 and by the related growth factor IGF2. It belongs to the large class of tyrosine kinase receptors. This receptor mediates the effects of IGF1, which is a polypeptide hormone similar in molecular structure to insulin. IGF1R is made up of two alpha subunits and two beta subunits. Both the alpha and beta subunits are synthesized from a single mRNA precursor. The precursor is then glycosylated, proteolytically cleaved, and crosslinked by disulfide bonds to form a functional transmembrane alphabeta chain. The alpha chains are located extracellularly, while the beta subunits span the membrane and are responsible for intracellular signal transduction upon ligand stimulation. IGF1R has a binding site for ATP, which is used to provide the phosphates for autophosphorylation. There is 60% sequence homology between IGF1R and the insulin receptor. In response to ligand binding, the alpha chains induce the tyrosine autophosphorylation of the beta chains. This event triggers a cascade of intracellular signaling that, while somewhat cell type specific, often promotes cell survival and cell proliferation. - Proteine/Peptide
