Cynomolgus IL-10 Protein, His Tag, Unconjugated, Human

Product Overview

• Article Name: Cynomolgus IL-10 Protein, His Tag, Unconjugated, Human
• Biozol Catalog Number: ABS-IL0-C4248-20UG
• Supplier Catalog Number: IL0-C4248-20ug
• Alternative Catalog Number: ABS-IL0-C4248-20UG
• Manufacturer: AcroBiosystems
• Host: Human
• Category: Proteine/Peptide
• Species Reactivity: Monkey
• Conjugation: Unconjugated

Product Description

Interleukin10 (IL10) is also known as human cytokine synthesis inhibitory factor (CSIF), is an antiinflammatory cytokine. IL10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. Mature human IL10 shares 72% 86% amino acid sequence identity with bovine, canine, equine, feline, mouse, ovine, porcine, and rat IL10. Whereas human IL10 is active on mouse cells, mouse IL10 does not act on human cells. IL10 is capable of inhibiting synthesis of proinflammatory cytokines such as IFNgamma, IL2, IL3, TNFalpha and GMCSF made by cells such as macrophages and regulatory Tcells. It also displays a potent ability to suppress the antigenpresentation capacity of antigen presenting cells. However, it is also stimulatory towards certain T cells and mast cells and stimulates B cell maturation and antibody production. Knockout studies suggested the function of Interleukin10 / IL10 as an essential immunoregulator in the intestinal tract. Patients with Crohns disease react favorably towards treatment with bacteria producing recombinant interleukin10, showing the importance of interleukin10 for counteracting excessive immunity in the human body. - Proteine/Peptide

Product Properties

• Molecular Weight: 20.6 kDa
• Tag: N-10*His
• NCBI: 79338
• Buffer: PBS, pH7.4
• Purity: 90%
• Form: Powder
• Target: IL-10

Images

Immobilized Cynomolgus IL-10 R alpha Protein, Fc Tag (Cat. No. ILR-C5256) at 5 µg/mL (100 µL/well) can bind Cynomolgus IL-10 Protein, His Tag (Cat. No. IL0-C4248) with a linear range of 0.01-0.313 µg/mL (QC tested).

Immobilized Cynomolgus IL-10 Protein, His Tag (Cat. No. IL0-C4248) at 5 µg/mL (100 µL/well) can bind Cynomolgus IL-10 R alpha Protein, Fc Tag (Cat. No. ILR-C5256) with a linear range of 0.1-2 ng/mL (Routinely tested).

Cynomolgus IL-10 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.