Human IL-1 RII / CD121b Protein, Fc Tag, Unconjugated

Product Overview

• Article Name: Human IL-1 RII / CD121b Protein, Fc Tag, Unconjugated
• Biozol Catalog Number: ABS-IL2-H4256-100UG
• Supplier Catalog Number: IL2-H4256-100ug
• Alternative Catalog Number: ABS-IL2-H4256-100UG
• Manufacturer: AcroBiosystems
• Host: Human
• Category: Proteine/Peptide
• Species Reactivity: Human
• Conjugation: Unconjugated

Product Description

Interleukin1 receptor type 2 (IL1R2) is also known as CD121 antigenlike family member B (CDw121b), IL1 type II receptor, Interleukin1 receptor type II, belongs to the interleukin1 receptor family. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1R2 is nonsignaling receptor for IL1A, IL1B and IL1RN, reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. IL1R2 modulates cellular response through nonsignaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity, this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. - Proteine/Peptide

Product Properties

• Molecular Weight: 63.9 kDa
• Tag: C-Fc
• NCBI: 004624
• Buffer: 50 mM Tris, 100 mM Glycine, 150 mM NaCl, pH7.5
• Purity: 95%
• Form: Powder
• Target: IL-1 RII

Images

Immobilized Human IL-1 beta, premium grade (Cat. No. ILB-H4110) at 10 µg/mL (100 µL/well) can bind Human IL-1 RII, Fc Tag (Cat. No. IL2-H4256) with a linear range of 4-63 ng/mL (QC tested).

Human IL-1 RII, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

IL2-H4256-100ug