CytoPak Human IL-2 Protein, premium grade, Unconjugated, E. coli
Biozol Catalog Number:
ABS-IL2-H5113GB02-3*105IU
Supplier Catalog Number:
IL2-H5113GB02-3*10 5IU
Alternative Catalog Number:
ABS-IL2-H5113GB02-3X105IU
Manufacturer:
AcroBiosystems
Host:
E. coli
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Unconjugated
Interleukin2 (IL2) is an interleukin, a type of cytokine immune system signaling molecule, which is a leukocytotrophic hormone that is instrumental in the bodys natural response to microbial infection and in discriminating between foreign (nonself) and self. IL2 mediates its effects by binding to IL2 receptors, which are expressed by lymphocytes, the cells that are responsible for immunity. Mature human IL2 shares 56% and 66% aa sequence identity with mouse and rat IL2, respectively. Human and mouse IL2 exhibit crossspecies activity. The receptor for IL2 consists of three subunits that are present on the cell surface in varying preformed complexes. IL2 is also necessary during T cell development in the thymus for the maturation of a unique subset of T cells that are termed regulatory T cells (Tregs). After exiting from the thymus, TRegs function to prevent other T cells from recognizing and reacting against self antigens, which could result in autoimmunity. TRegs do so by preventing the responding cells from producing IL2. Thus, IL2 is required to discriminate between self and nonself, another one of the unique characteristics of the immune system. - Proteine/Peptide
