Human IL-13 R alpha 2 Protein, Fc Tag (MALS verified), Unconjugated

Product Overview

• Article Name: Human IL-13 R alpha 2 Protein, Fc Tag (MALS verified), Unconjugated
• Biozol Catalog Number: ABS-IL2-H5256-1MG
• Supplier Catalog Number: IL2-H5256-1mg
• Alternative Catalog Number: ABS-IL2-H5256-1MG
• Manufacturer: AcroBiosystems
• Host: Human
• Category: Proteine/Peptide
• Species Reactivity: Human
• Conjugation: Unconjugated

Product Description

Interleukin13 receptor subunit alpha2 is also known as IL13Ralpha2, IL13Ra2 cluster of differentiation 213A2, CD213A2, CT19, IL13R, IL13BP, and is a membrane bound protein that in humans is encoded by the IL13RA2 gene. IL13Ralpha2 is closely related to IL13Ralpha1, a subunit of the interleukin13 receptor complex. This protein binds IL13 with high affinity, but lacks any significant cytoplasmic domain, and does not appear to function as a signal mediator. It is, however able to regulate the effects of both IL13 and IL4, despite the fact it is unable to bind directly to the latter. It is also reported to play a role in the internalization of IL13. IL13Ralpha2 is a component of the cell surface receptors, however, the majority exists in intracellular pools and in soluble form, and thus plays an opposite role as a potent IL13 antagonist compared with IL13Ralpha1. It also functions as an inhibitor of IL4dependent pathway probably through the physical interaction between the short intracellular domain of and cytoplasmic domain of IL13Ralpha2 and the IL4Ralpha chain. In spite of the failed STAT signaling function, IL13Ralpha2 dose induce TGFbeta production and fibrosis. Additionally, IL13Ralpha2has been reported to be abundantly and specifically overexpressed in glioblastoma multiforme. - Proteine/Peptide

Product Properties

• Molecular Weight: 63.5 kDa
• Tag: N-Fc
• NCBI: 000631
• Buffer: PBS, pH7.4
• Purity: 90%
• Form: Powder
• Target: IL-13 R alpha 2

Images

Immobilized Human IL-13 Protein, His Tag, premium grade (Cat. No. IL3-H52H3) at 5 µg/mL (100 µL/well) can bind Human IL-13 R alpha 2 Protein, Fc Tag (Cat. No. IL2-H5256) with a linear range of 1-39 ng/mL (QC tested).

Immobilized Human IL-13 R alpha 2 Protein, Fc Tag (Cat. No. IL2-H5256) at 1 µg/mL (100 µL/well) can bind Monoclonal Anti-IL-13 R alpha 2 Antibody, Mouse IgG1 with a linear range of 0.2-6 ng/mL (QC tested).

Human IL-13 R alpha 2 Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.