Interleukin2 (IL2) is an interleukin, a type of cytokine immune system signaling molecule, which is a leukocytotrophic hormone that is instrumental in the bodys natural response to microbial infection and in discriminating between foreign (nonself) and self. IL2 mediates its effects by binding to IL2 receptors, which are expressed by lymphocytes, the cells that are responsible for immunity. Mature human IL2 shares 56% and 66% aa sequence identity with mouse and rat IL2, respectively. Human and mouse IL2 exhibit crossspecies activity. The receptor for IL2 consists of three subunits that are present on the cell surface in varying preformed complexes. IL2 is also necessary during T cell development in the thymus for the maturation of a unique subset of T cells that are termed regulatory T cells (Tregs). After exiting from the thymus, TRegs function to prevent other T cells from recognizing and reacting against self antigens, which could result in autoimmunity. TRegs do so by preventing the responding cells from producing IL2. Thus, IL2 is required to discriminate between self and nonself, another one of the unique characteristics of the immune system. - Proteine/Peptide
Immobilized Mouse IL-2, His Tag (Cat. No. IL2-M52H3) at 5 µg/mL (100 µL/well) can bind Mouse IL-2RB&IL-2RA&IL-2RG, Fc Tag&Fc Tag (Cat. No. ILG-M5253) with a linear range of 0.8-3 ng/mL (QC tested).
Mouse IL-2, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
IL2-M52H3-1mg
* VAT and and shipping costs not included. Errors and price changes excepted
