Interleukin4, is a cytokine that induces differentiation of naive helper T cells (Th0 cells to Th2 cells). In the presence of IL4 and IL13, cytokines that are produced in a Th2 type response, particularly during allergy and parasitic infections, macrophages become differentially activated, And this cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. Recently, researcher found that the cytokine IL4 plays a key role in development of innate CD8+ T cells in the thymus of several genedeficient mouse strains, including Itk, KLF2, CBP and Id3, without previous exposure to antigen. - Proteine/Peptide
Immobilized Human IL-4, premium grade (Cat. No. IL4-H4218) at 5 µg/mL (100 µL/well) can bind Human IL-4 R alpha, Fc Tag (Cat. No. ILR-H5253) with a linear range of 0.001-0.031 µg/mL (QC tested).
Immobilized Human IL-4, premium grade (Cat. No. IL4-H4218) at 5 µg/mL (100 µL/well) can bind Biotinylated Human IL-4 R alpha, Fc,Avitag (Cat. No. ILR-H82F4) with a linear range of 0.008-0.125 µg/mL (Routinely tested).
Human IL-4, premium grade on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
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