Interleukin 5 (IL5) is an interleukin produced by type2 T helper cells and mast cells. IL5 is a 115amino acid (in human, 133 in the mouse) long TH2 cytokine that is part of the hematopoietic family. Unlike other members of this cytokine family (namely interleukin 3 and GMCSF), this glycoprotein in its active form is a homodimer. Interleukin5 has long been associated with the cause of several allergic diseases including allergic rhinitis and asthma, wherein a large increase in the number of circulating, airway tissue, and induced sputum eosinophils have been observed. Given the high concordance of eosinophils and, in particular, allergic asthma pathology, it has been widely speculated that eosinophils have an important role in the pathology of this disease. Drugs that target IL5 are mepolizumab and reslizumab. - Proteine/Peptide
Immobilized Human IL-5 Protein, His Tag (Cat. No. IL5-H52H3) at 5 µg/mL (100 µL/well) can bind Human IL-5 R alpha, Fc Tag (Cat. No. ILA-H5269) with a linear range of 0.6-10 ng/mL (QC tested).
Human IL-5 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
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