Human IL-29 / IFN-lambda 1 Protein, His Tag, Unconjugated
Biozol Catalog Number:
ABS-IL9-H4228-20UG
Supplier Catalog Number:
IL9-H4228-20ug
Alternative Catalog Number:
ABS-IL9-H4228-20UG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Unconjugated
Interleukin29, is a secreted protein which belongs to the IL28 / IL29 family, and is a type III interferon. It is also known as cytokine Zcyto21, Interferon lambda1, IFNlambda1, IFNlambda1, IL29 and IFNL1, and is highly similar in amino acid sequence to the IL28, the other type III interferon. IL28A, IL28B, and IL29, also named interferonlambda2 (IFNlambda2), IFNlambda3, and IFNlambda1, respectively, are classII cytokine receptor ligands that are distantly related to members of the IL 10 family (1113% aa sequence identity) and the type I IFN family (1519% aa sequence identity). Human IL29 cDNA encodes a 200 amino acid (aa) residue precursor protein with a putative 19 aa signal peptide and a 181 aa mature protein, which is a monomer in solution. It shares 67% and 69% aa sequence identity with human IL28A and IL28B, respectively. IL29 plays an important role in host defenses against microbes and its gene is highly upregulated in cells infected with viruses and also may play a role in antiviral immunity. Interleukin29 / IL29 upregulates MHC class I antigen expression. It is a Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the JakSTAT pathway. - Proteine/Peptide
Human IL-29, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
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