Cynomolgus IL-1 beta / IL-1F2 Protein, His Tag, Unconjugated, E. coli
Biozol Catalog Number:
ABS-ILB-C51H3-1MG
Supplier Catalog Number:
ILB-C51H3-1mg
Alternative Catalog Number:
ABS-ILB-C51H3-1MG
Manufacturer:
AcroBiosystems
Host:
E. coli
Category:
Proteine/Peptide
Species Reactivity:
Monkey
Conjugation:
Unconjugated
Interleukin1 beta (IL1beta) is also known as catabolin, is a cytokine protein that in humans is encoded by the IL1B gene. IL1beta precursor is cleaved by caspase 1 (interleukin 1 beta convertase). Cytosolic thiol protease cleaves the product to form mature IL1 beta. IL1beta are structurally related polypeptides that share approximately 21% amino acid (aa) identity in human. Both proteins are produced by a wide variety of cells in response to inflammatory agents, infections, or microbial endotoxins. While IL1alpha and IL1beta are regulated independently, they bind to the same receptor and exert identical biological effects. IL1beta is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. - Proteine/Peptide
Cynomolgus IL-1 beta, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
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