Biotinylated Human IL-23 R Protein, Fc,Avitag(TM) (MALS verified)
Biozol Catalog Number:
ABS-ILR-H82F3-25UG
Supplier Catalog Number:
ILR-H82F3-25ug
Alternative Catalog Number:
ABS-ILR-H82F3-25UG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Biotin
Interleukin 23 receptor (IL23R) is a type I cytokine receptor, and IL23R pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. Also, IL23R associates constitutively with Janus kinase 2 (JAK2), and binds to transcription activator STAT3 in a liganddependent manner. Furthermore, IL23R mediates Tcells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the JakStat signaling cascade. As for IL23, it may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis. - Proteine/Peptide
Immobilized Biotinylated Human IL-23 R, Fc,Avitag (Cat. No. ILR-H82F3) at 5 µg/mL (100 µL/well) on Streptavidin precoated (0.5 µg/well) plate can bind Human IL-23A&IL-12B Heterodimer Protein, His Tag&Tag Free (Cat. No. ILB-H52W5) with a linear range of 39-156 ng/mL (QC tested).
Immobilized Biotinylated Human IL-23 R, Fc,Avitag (Cat. No. ILR-H82F3) at 5 µg/mL (100 µL/well), can bind pre-mixed increasing concentrations of Human IL23A/p19 Neutralizing Antibody and 0.25 µg/mL (100 µL/well) Human IL-23A&IL-12B Heterodimer Protein, His Tag&Tag Free (Cat. No. ILB-H52W5) with a half maximal inhibitory concentration (IC50) of 0.3889 µg/mL (Routinely tested).
Biotinylated Human IL-23 R, Fc,Avitag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
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