Mouse IL-10 R alpha / CD210 Protein, Fc Tag, Unconjugated, Human
Biozol Catalog Number:
ABS-ILR-M5254-100UG
Supplier Catalog Number:
ILR-M5254-100ug
Alternative Catalog Number:
ABS-ILR-M5254-100UG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Mouse
Conjugation:
Unconjugated
Interleukin10 receptor subunit alpha (IL10 R alpha ) is a cell surface receptor for the cytokine IL10 that participates in IL10 mediated antiinflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well.In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively.These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3. - Proteine/Peptide
Immobilized Human IL-10, His Tag (Cat. No. IL0-H4248) at 5 µg/mL (100 µL/well) can bind Mouse IL-10 R alpha Protein, Fc Tag (Cat. No. ILR-M5254) with a linear range of 0.002-0.063 µg/mL (QC tested).
Mouse IL-10 R alpha Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
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