Cynomolgus Integrin alpha V beta 5 (ITGAV&ITGB5) Heterodimer Protein, His Tag&Tag Free (MALS verified), Unconjugated, Human

Product Overview

• Article Name: Cynomolgus Integrin alpha V beta 5 (ITGAV&ITGB5) Heterodimer Protein, His Tag&Tag Free (MALS verified), Unconjugated, Human
• Biozol Catalog Number: ABS-IT5-C52W3-100UG
• Supplier Catalog Number: IT5-C52W3-100ug
• Alternative Catalog Number: ABS-IT5-C52W3-100UG
• Manufacturer: AcroBiosystems
• Host: Human
• Category: Proteine/Peptide
• Species Reactivity: Monkey
• Conjugation: Unconjugated

Product Description

Integrin alpha V beta 5 (ITGAV & ITGB5) is expressed on a wide variety of cell types including keratinocytes, fibroblasts, adhesive monocytes, embryonic stem cells, and select endothelium and epithelium. ITGAV & ITGB5 binds ligands containing an RGD motif, notably vitronectin. Growth factors that increase PKC activity, such as VEGF or TGF alpha, promote ITGAV & ITGB5mediated angiogenesis while alpha V beta 3, which may be expressed in the same cell, responds to FGFbasic and TNF alpha. An inhibitor of both down regulates tumor angiogenesis. During lung inflammation, up regulation of ITGAV & ITGB5 on myofibroblasts or infiltrating lymphocytes may contribute to fibrosis by freeing TGF beta from latency. - Proteine/Peptide

Product Properties

• Molecular Weight: 113.1 kDa & 81.8 kDa
• Tag: C-10*His | Native
• NCBI: 0
• Buffer: 50 mM Tris, 150 mM NaCl, pH7.5
• Purity: 90%
• Form: Powder
• Target: Integrin alpha V beta 5

Images

Cynomolgus Integrin alpha V beta 5 (ITGAV&ITGB5) Heterodimer Protein, His Tag&Tag Free on SDS-PAGE under non-reducing (NR) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.