Biotinylated Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His,Avitag(TM)&Tag Free (MALS verified)

Product Overview

• Article Name: Biotinylated Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His,Avitag(TM)&Tag Free (MALS verified)
• Biozol Catalog Number: ABS-IT6-H82E4-25UG
• Supplier Catalog Number: IT6-H82E4-25ug
• Alternative Catalog Number: ABS-IT6-H82E4-25UG
• Manufacturer: AcroBiosystems
• Host: Human
• Category: Proteine/Peptide
• Species Reactivity: Human
• Conjugation: Biotin

Product Description

Integrin alpha V beta 6 is a heterodimer of beta6 associating with alphaV. Integrin alphaV beta6 is a receptor for fibronectin and cytotactin. It recognizes the sequence RGD in its ligands. Internalisation of integrin alphaV beta6 via clathrinmediated endocytosis promotes carcinoma cell invasion. Also, Integrin alphaV beta6 acts as a receptor for coxsackievirus A9 and coxsackievirus B1 as well as herpes simplex virus1/HHV1. Furthermore, it binds the TGFbeta latency-associated peptide (LAP) and activates TGFbeta 1 or TGFbeta 3 from large latent complexes. This activation requires interaction with LTBP1 and fibronectin, and is enhanced by PAR1. - Proteine/Peptide

Product Properties

• Molecular Weight: 114.7 kDa (ITGAV) & 79.6 kDa (ITGB6)
• Tag: C-10*His & C-Avi | Native
• NCBI: 002201
• Buffer: 50 mM Tris, 150 mM NaCl, pH7.5
• Purity: 90%
• Form: Powder
• Target: Integrin alpha V beta 6

Images

Immobilized Human Latent TGFB1, His Tag (Cat. No. TG1-H524x) at 5 µg/mL (100 µL/well) can bind Biotinylated Human ITGAV&ITGB6 Heterodimer Protein, His,Avitag&Tag Free (Cat. No. IT6-H82E4) with a linear range of 5-39 ng/mL (QC tested).

Immobilized Fibronectin at 10 µg/mL (100 µL/well) can bind Biotinylated Human ITGAV&ITGB6 Heterodimer Protein, His,Avitag&Tag Free (Cat. No. IT6-H82E4) with a linear range of 0.078-1.25 µg/mL (Routinely tested).

Biotinylated Human ITGAV&ITGB6 Heterodimer Protein, His,Avitag&Tag Free on SDS-PAGE under non-reducing (NR) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.