Rat Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His Tag&Tag Free (MALS verified), Unconjugated, Human
Biozol Catalog Number:
ABS-IT6-R52E6-100UG
Supplier Catalog Number:
IT6-R52E6-100ug
Alternative Catalog Number:
ABS-IT6-R52E6-100UG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Rat
Conjugation:
Unconjugated
Integrin alpha V beta 6 is a heterodimer of beta6 associating with alphaV. Integrin alphaV beta6 is a receptor for fibronectin and cytotactin. It recognizes the sequence RGD in its ligands. Internalisation of integrin alphaV beta6 via clathrinmediated endocytosis promotes carcinoma cell invasion. Also, Integrin alphaV beta6 acts as a receptor for coxsackievirus A9 and coxsackievirus B1 as well as herpes simplex virus1/HHV1. Furthermore, it binds the TGFbeta latency-associated peptide (LAP) and activates TGFbeta 1 or TGFbeta 3 from large latent complexes. This activation requires interaction with LTBP1 and fibronectin, and is enhanced by PAR1. - Proteine/Peptide
Immobilized Human Fibronectin at 5 µg/mL (100 µL/well) can bind Rat ITGAV&ITGB6 Heterodimer, His Tag&Tag Free (Cat. No. IT6-R52E6) with a linear range of 0.02-0.625 µg/mL (QC tested).
Immobilized Rat ITGAV&ITGB6 Heterodimer, His Tag&Tag Free (Cat. No. IT6-R52E6) at 5 µg/mL (100 µL/well) can bind Biotinylated Human Latent TGF-Beta 1, His,Avitag (Cat. No. TG1-H82Qb) with a linear range of 0.3-10 ng/mL (Routinely tested).
Rat ITGAV&ITGB6 Heterodimer, His Tag&Tag Free on SDS-PAGE under non-reducing (NR) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
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