Human Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer Protein, His Tag&Tag Free, Unconjugated
Biozol Catalog Number:
ABS-IT8-H52W4-1MG
Supplier Catalog Number:
IT8-H52W4-1mg
Alternative Catalog Number:
ABS-IT8-H52W4-1MG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Unconjugated
Integrin alpha V beta 8 (ITGAV & ITGB8 or ITGAVB8) is expressed in yolk sac, placenta, brain perivascular astrocytes, Schwann cells, renal glomerular mesangial cells and pulmonary epithelial cells. Unlike other alpha V integrins, ITGAVB8 does not appear to assume different activation states, and the cytoplasmic tail does not connect to the cytoskeleton. It binds ligands containing an RGD motif, including vitronectin, fibrin and the latency associated peptide (LAP) of the latent TGFbeta complex. High affinity binding of alpha V beta 8 to LAP allows proteolytic cleavage by MT1MMP, which releases active TGFbeta. This mechanism differs from that of alpha V beta 6, the other alpha V integrin which can activate TGFbeta from latency through nonproteolytic mechanisms. Downstream effects of TGFbeta activation include control of cell growth and associated vascularization. - Proteine/Peptide
Immobilized Human ITGAV&ITGB8 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT8-H52W4) at 5 µg/mL (100 µL/well) can bind Biotinylated Human Latent TGF-Beta 1, His,Avitag (Cat. No. TG1-H82Qb) with a linear range of 1-31 ng/mL (QC tested).
Immobilized Human Fibronectin at 10 µg/mL (100 µL/well) can bind Human ITGAV&ITGB8 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT8-H52W4) with a linear range of 0.313-10 µg/mL (Routinely tested).
Human ITGAV&ITGB8 Heterodimer Protein, His Tag&Tag Free on SDS-PAGE under non-reducing (NR) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
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