Mouse Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer Protein, His Tag&Tag Free (MALS verified), Unconjugated, Human

Product Overview

• Article Name: Mouse Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer Protein, His Tag&Tag Free (MALS verified), Unconjugated, Human
• Biozol Catalog Number: ABS-IT8-M52W6-100UG
• Supplier Catalog Number: IT8-M52W6-100ug
• Alternative Catalog Number: ABS-IT8-M52W6-100UG
• Manufacturer: AcroBiosystems
• Host: Human
• Category: Proteine/Peptide
• Species Reactivity: Mouse
• Conjugation: Unconjugated

Product Description

Integrin alpha V beta 8 (ITGAV & ITGB8 or ITGAVB8) is expressed in yolk sac, placenta, brain perivascular astrocytes, Schwann cells, renal glomerular mesangial cells and pulmonary epithelial cells. Unlike other alpha V integrins, ITGAVB8 does not appear to assume different activation states, and the cytoplasmic tail does not connect to the cytoskeleton. It binds ligands containing an RGD motif, including vitronectin, fibrin and the latency associated peptide (LAP) of the latent TGFbeta complex. High affinity binding of alpha V beta 8 to LAP allows proteolytic cleavage by MT1MMP, which releases active TGFbeta. This mechanism differs from that of alpha V beta 6, the other alpha V integrin which can activate TGFbeta from latency through nonproteolytic mechanisms. Downstream effects of TGFbeta activation include control of cell growth and associated vascularization. - Proteine/Peptide

Product Properties

• Molecular Weight: 112.5 kDa (ITGAV) & 77.5 kDa (ITGB8)
• Tag: C-10*His | Native
• NCBI: 43406
• Buffer: 50 mM Tris, 150 mM NaCl, pH7.5
• Purity: 95%
• Form: Powder
• Target: Integrin alpha V beta 8

Images

Immobilized Mouse ITGAV&ITGB8 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT8-M52W6) at 5 µg/mL (100 µL/well) can bind Biotinylated Human Latent TGF-Beta 1, His,Avitag (Cat. No. TG1-H82Qb) with a linear range of 1-10 ng/mL (QC tested).

Immobilized Human Fibronectin at 2 µg/mL (100 µL/well) can bind Mouse ITGAV&ITGB8 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT8-M52W6) with a linear range of 0.156-5 µg/mL (Routinely tested).

Mouse ITGAV&ITGB8 Heterodimer Protein, His Tag&Tag Free on SDS-PAGE under non-reducing (NR) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.