Biotinylated Human VEGF R2 / KDR Protein, Avitag(TM),His Tag

Product Overview

• Article Name: Biotinylated Human VEGF R2 / KDR Protein, Avitag(TM),His Tag
• Biozol Catalog Number: ABS-KDR-H82E5-25UG
• Supplier Catalog Number: KDR-H82E5-25ug
• Alternative Catalog Number: ABS-KDR-H82E5-25UG
• Manufacturer: AcroBiosystems
• Host: Human
• Category: Proteine/Peptide
• Species Reactivity: Human
• Conjugation: Biotin

Product Description

Kinase insert domain receptor (KDR) is also known as CD309, FLK1, VEGFR, VEGFR2, and is one of the subtypes of VEGFR. VEGF receptors are receptors for vascular endothelial growth factor (VEGF). There are three main subtypes of VEGFR, numbered 1, 2 and 3. The VEGF receptors have an extracellular portion consisting of 7 immunoglobulinlike domains, a single transmembrane spanning region and an intracellular portion containing a split tyrosinekinase domain. VEGFA binds to VEGFR1 (Flt1) and VEGFR2 (KDR/Flk1). VEGFR2 appears to mediate almost all of the known cellular responses to VEGF.The function of VEGFR1 is less well defined, although it is thought to modulate VEGFR2 signaling. Another function of VEGFR1 may be to act as a dummy/decoy receptor, sequestering VEGF from VEGFR2 binding (this appears to be particularly important during vasculogenesis in the embryo). In addition, VEGFR2 is able to interact with HIV1 extracellular Tat protein upon VEGF activation, and seems to enhance angiogenesis in Kaposis sarcoma lesions. - Proteine/Peptide

Product Properties

• Molecular Weight: 85.9 kDa
• Tag: C-Avi & C-6*His
• NCBI: 31823
• Buffer: PBS, pH7.4
• Purity: 95%
• Form: Powder
• Target: VEGF R2

Images

Immobilized Human VEGF165, premium grade (Cat. No. VE5-H4210) at 2 µg/mL (100 µL/well) can bind Biotinylated Human VEGF R2, Avitag,His Tag (Cat. No. KDR-H82E5) with a linear range of 10-156 ng/mL (QC tested).

Immobilized Human VEGF165, premium grade (Cat. No. VE5-H4210) at 2 µg/mL (100 µL/well) can bind pre-mixed increasing concentrations of Bevacizumab and 0.5 µg/mL (100 µL/well) Biotinylated Human VEGF R2, Avitag,His Tag (Cat. No. KDR-H82E5) with a half maximal inhibitory concentration (IC50) of 0.70 µg/mL (Routinely tested).

KDR-H82E5-25ug

Biotinylated Human VEGF R2, Avitag,His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.