Human LAMP5 / BAD-LAMP Protein, His Tag, Unconjugated

Product Overview

• Article Name: Human LAMP5 / BAD-LAMP Protein, His Tag, Unconjugated
• Biozol Catalog Number: ABS-LA5-H52H9-500UG
• Supplier Catalog Number: LA5-H52H9-500ug
• Alternative Catalog Number: ABS-LA5-H52H9-500UG
• Manufacturer: AcroBiosystems
• Host: Human
• Category: Proteine/Peptide
• Species Reactivity: Human
• Conjugation: Unconjugated

Product Description

LAMPs (lysosome associated membrane proteins) represent a family of glycosylated proteins present predominantly on the membrane of lysosomes whose expression can vary among different tissues, suggesting a separation of functions. LAMP5 is expressed highly and specifically in MLLr leukemia. LAMP5 is a direct target of the oncogenic MLLfusion protein. LAMP5 depletion significantly inhibited leukemia cell growth in vitro and in vivo. Functional studies showed that LAMP5 is a novel modulator of innateimmune pathways in MLLr leukemias. Downregulation of LAMP5 led to inhibition of NFkappaB signaling and increased activation of type1 interferon signaling downstream of Tolllike Receptor/Interleukin 1 Receptor activation. - Proteine/Peptide

Product Properties

• Molecular Weight: 25 kDa
• Tag: C-10*His
• NCBI: 9
• Buffer: PBS, pH7.4
• Purity: 95%
• Form: Powder
• Target: LAMP5

Images

Human LAMP5, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.