LowDensity Lipoprotein (LDL) Receptor is also known as LDLR, FH, FHC, LDLCQ2, and is a mosaic protein of ~840 amino acids (after removal of signal peptide) that mediates the endocytosis of cholesterolrich LDL. It is a cellsurface receptor that recognizes the apoprotein B100 which is embedded in the phospholipid outer layer of LDL particles. The receptor also recognizes the apoE protein found in chylomicron remnants and VLDL remnants (IDL). It belongs to the Low density lipoprotein receptor gene family. LDL receptor complexes are present in clathrincoated pits (or buds) on the cell surface, which when bound to LDLcholesterol via adaptin, are pinched off to form clathrincoated vesicles inside the cell. This allows LDLcholesterol to be bound and internalized in a process known as endocytosis and prevents the LDL just diffusing around the membrane surface. This occurs in all nucleated cells (not erythrocytes), but mainly in the liver which removes ~70% of LDL from the circulation. Synthesis of receptors in the cell is regulated by the level of free intracellular cholesterol, if it is in excess for the needs of the cell then the transcription of the receptor gene will be inhibited. LDL receptors are translated by ribosomes on the endoplasmic reticulum and are modified by the Golgi apparatus before travelling in vesicles to the cell surface. LDL is directly involved in the development of atherosclerosis, due to accumulation of LDLcholesterol in the blood. Atherosclerosis is the process responsible for the majority of cardiovascular diseases. - Proteine/Peptide
Immobilized Human PCSK9 Propeptide & Rabbit Mature PCSK9 (154-686), His Tag at 2 µg/mL (100 µL/well) can bind Rabbit LDL R, Fc Tag (Cat. No. LDR-R5255) with a linear range of 2-78 ng/mL (QC tested).
Rabbit LDL R, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
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