Biotinylated Human LOXL2 Protein, His,Avitag(TM) (active enzyme)
Biozol Catalog Number:
ABS-LO2-H82E3-200UG
Supplier Catalog Number:
LO2-H82E3-200ug
Alternative Catalog Number:
ABS-LO2-H82E3-200UG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Biotin
Lysyl oxidase homolog 2 is also known as LOXL2, Lysyl oxidaselike protein 2, which is expressed in many tissues, highest expression in reproductive tissues, placenta, uterus and prostate, Upregulated in a number of cancers cells and tissues. LOXL2 mediates the posttranslational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes crosslinking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. LOXL2 acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated Lys4 of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. LOXL2 acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation. - Proteine/Peptide
