Lowdensity lipoprotein receptorrelated protein 5(LRP5) is also known as BMND1, EVR1, EVR4, HBM, LR3, LRP7, OPPG, OPTA1, VBCH2, LDL receptor related protein 5 and PCLD4. LRP5 is a transmembrane lowdensity lipoprotein receptor that shares a similar structure with LRP6. LRP5 acts as a coreceptor with LRP6 and the Frizzled protein family members for transducing signals by Wnt proteins through the canonical Wnt pathway. This protein plays a key role in skeletal homeostasis. Mutations in LRP5 can lead to considerable changes in bone mass. A lossoffunction mutation causes osteoporosispseudoglioma (decrease in bone mass), while a gainoffunction mutation causes drastic increases in bone mass. - Proteine/Peptide
Immobilized Human Dkk-1, His Tag (Cat. No. DK1-H5221) at 5 µg/mL (100 µL/well) can bind Biotinylated Human LRP-5, His,Avitag (Cat. No. LR5-H82E6) with a linear range of 0.078-1.25 µg/mL (Routinely tested).
Biotinylated Human LRP-5, His,Avitag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
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