Biotinylated Human LRP-6 (20-630) Protein, His,Avitag(TM)
Biozol Catalog Number:
ABS-LR6-H82E7-25UG
Supplier Catalog Number:
LR6-H82E7-25ug
Alternative Catalog Number:
ABS-LR6-H82E7-25UG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Biotin
LRP6 is a transmembrane lowdensity lipoprotein receptor that shares a similar structure with LRP5. Lowdensity lipoprotein receptorrelated protein 6 is a key component of the LRP5/LRP6/Frizzled coreceptor group that is involved in canonical Wnt pathway. The Wntinduced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3Bcomplex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3mediated phosphorylation and destruction of betacatenin. - Proteine/Peptide