MAGP2 (Microfibrilassociated glycoprotein 2), also called MFAP5 (microfibrillar associated protein 5) is a secreted, cellassociated 25 kDa mammalian member of the MFAP family of proteins. Both MAGP1 and MAGP2 bind and covalently crosslink Fibrillin1 and 2 through the Cysrich binding domain. Functionally, the MAGP2 RGD motif binds to the integrin alpha v beta 3, allowing cell attachment to microfibrils. MAGP-2 is thought to facilitate microfibril assembly and induce elastin fiber formation. Through its binding to EGF repeats, MAGP-2 mediates the metalloproteinasedependent release of Jagged1, and the metalloproteinaseindependent release of Notch extracellular domains. In endothelial cells, MAGP2 promotes angiogenic sprouting by inhibiting Notch signaling, by binding to integrin alpha v beta 3 (which then enhances VEGF signaling), and/or enhancing the endothelial cell response to FGF basic and EGF. In ovarian cancer, MAGP2 expression is associated with cancer cell survival, increased microvessel density, and poor prognosis. - Proteine/Peptide
