Mouse MCAM / CD146 Protein, His Tag, Unconjugated, Human

Product Overview

• Article Name: Mouse MCAM / CD146 Protein, His Tag, Unconjugated, Human
• Biozol Catalog Number: ABS-MCM-M52H3-100UG
• Supplier Catalog Number: MCM-M52H3-100ug
• Alternative Catalog Number: ABS-MCM-M52H3-100UG
• Manufacturer: AcroBiosystems
• Host: Human
• Category: Proteine/Peptide
• Species Reactivity: Mouse
• Conjugation: Unconjugated

Product Description

CD146, also known as the melanoma cell adhesion molecule (MCAM) or cell surface glycoprotein MUC18, is a 113kDa cell adhesion molecule currently used as a marker for endothelial cell lineage. As a member of the Immunoglobulin superfamily, It is expressed on chicken embryonic spleen and thymus, activated human T cells, endothelial progenitors such as angioblasts and mesenchymal stem cells, and strongly expressed on blood vessel endothelium and smooth muscle. CD146 has been demonstrated to appear on a small subset of T and B lymphocytes in the peripheral blood of healthy individuals. The CD146+ T cells display an immunophenotype consistent with effector memory cells and have a distinct gene profile from the CD146 T cells. As a Ca2+ independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor,CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis or immune recognition. - Proteine/Peptide

Product Properties

• Molecular Weight: 61.7 kDa
• Tag: C-10*His
• NCBI: 8
• Buffer: PBS, pH7.4
• Purity: 95%
• Form: Powder
• Target: MCAM

Images

Mouse MCAM, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.