Cynomolgus MERTK / Mer Protein, Fc Tag (MALS verified), Unconjugated, Human

Product Overview

• Article Name: Cynomolgus MERTK / Mer Protein, Fc Tag (MALS verified), Unconjugated, Human
• Biozol Catalog Number: ABS-MEK-C5253-100UG
• Supplier Catalog Number: MEK-C5253-100ug
• Alternative Catalog Number: ABS-MEK-C5253-100UG
• Manufacturer: AcroBiosystems
• Host: Human
• Category: Proteine/Peptide
• Species Reactivity: Monkey
• Conjugation: Unconjugated

Product Description

Tyrosineprotein kinase Mer(MERTK) is a member of the TYRO3/AXL/MER (TAM) receptor kinase family and encodes a transmembrane protein with two fibronectin typeIII domains, two Iglike C2type (immunoglobulinlike) domains, and one tyrosine kinase domain. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Tolllike receptors (TLRs)mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. - Proteine/Peptide

Product Properties

• Molecular Weight: 79.1 kDa
• Tag: C-Fc
• NCBI: 005575320
• Buffer: PBS, pH7.4
• Purity: 95%
• Form: Powder
• Target: MERTK

Images

Cynomolgus MERTK, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.