Mouse HGF R / c-MET Protein, His Tag (MALS verified), Unconjugated, Human

Product Overview

• Article Name: Mouse HGF R / c-MET Protein, His Tag (MALS verified), Unconjugated, Human
• Biozol Catalog Number: ABS-MET-M52H3-1MG
• Supplier Catalog Number: MET-M52H3-1mg
• Alternative Catalog Number: ABS-MET-M52H3-1MG
• Manufacturer: AcroBiosystems
• Host: Human
• Category: Proteine/Peptide
• Species Reactivity: Mouse
• Conjugation: Unconjugated

Product Description

Hepatocyte growth factor receptor (HGFR) is also known as mesenchymalepithelial transition factor (MET), cMet, and is a glycosylated receptor tyrosine kinase that plays a central role in epithelial morphogenesis and cancer development. HGFR protein possesses tyrosinekinase activity. The primary single chain precursor protein is posttranslationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. HGFR is normally expressed by cells of epithelial origin, while expression of HGF is restricted to cells of mesenchymal origin. Upon HGF stimulation, HGFR induces several biological responses that collectively give rise to a program known as invasive growth. Abnormal HGFR activation in cancer correlates with poor prognosis, where aberrantly active HGFR triggers tumor growth, formation of new blood vessels (angiogenesis) that supply the tumor with nutrients, and cancer spread to other organs (metastasis). HGFR is deregulated in many types of human malignancies including cancers of kidney, liver, stomach, breast, and brain. Normally, only stem cells and progenitor cells express HGFR, However, cancer stem cells are thought to hijack the ability of normal stem cells to express HGFR, and thus become the cause of cancer persistence and spread to other sites in the body. Various mutations in the HGFR gene are associated with papillary renal carcinoma. HGFR mediates a complex program known as invasive growth. Activation of HGFR triggers mitogenesis, and morphogenesis - Proteine/Peptide

Product Properties

• Molecular Weight: 32.1 kDa & 70.6 kDa
• Tag: C-10*His
• NCBI: 16056
• Buffer: PBS, pH7.4
• Purity: 90%
• Form: Powder
• Target: HGF R

Images

Immobilized Human HGF Protein, premium grade (Cat. No. HGF-H5218) at 5 µg/mL (100 µL/well) can bind Mouse HGF R / c-MET Protein, His Tag (Cat. No. MET-M52H3) with a linear range of 5-78 ng/mL (QC tested).

Immobilized Human HGF, Fc Tag (Cat. No. HGF-H5253) at 5 µg/mL (100 µL/well) can bind Mouse HGF R / c-MET Protein, His Tag (Cat. No. MET-M52H3) with a linear range of 2-78 ng/mL (Routinely tested).

Mouse HGF R / c-MET Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.