Biotinylated Human MR1&B2M Complex Protein (MALS verified)

Product Overview

• Article Name: Biotinylated Human MR1&B2M Complex Protein (MALS verified)
• Biozol Catalog Number: ABS-MRM-H82W5-200UG
• Supplier Catalog Number: MRM-H82W5-200ug
• Alternative Catalog Number: ABS-MRM-H82W5-200UG
• Manufacturer: AcroBiosystems
• Host: Human
• Category: Proteine/Peptide
• Species Reactivity: Human
• Conjugation: Biotin

Product Description

MR1 is also knwon as MHC class Irelated gene protein. Antigenpresenting molecule specialized in displaying microbial pyrimidinebased metabolites to alphabeta T cell receptors (TCR) on innatetype mucosalassociated invariant T (MAIT) cells. In complex with B2M preferentially presents riboflavinderived metabolites to semiinvariant TRAV12 TCRs on MAIT cells, guiding immune surveillance of the microbial metabolome at mucosal epithelial barriers. Signature pyrimidinebased microbial antigens are generated via nonenzymatic condensation of metabolite intermediates of the riboflavin pathway with byproducts arising from other metabolic pathways such as glycolysis. Typical potent antigenic metabolites are 5(2oxoethylideneamino)6Dribitylaminouracil (5OERU) and 5(2oxopropylideneamino)6Dribitylaminouracil (5OPRU), products of condensation of 5amino6Dribityaminouracil (5ARU) with glyoxal or methylglyoxal byproducts, respectively. - Proteine/Peptide

Product Properties

• Molecular Weight: 36.3 kDa and 11.7 kDa
• Tag: C-10*His & C-Avi
• NCBI: 95460
• Buffer: PBS, pH7.4
• Purity: 95%
• Form: Powder
• Target: MR1 & B2M

Images

Biotinylated Human MR1&B2M Complex Protein on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.