Human NKG2A / CD159a Protein, His Tag, Unconjugated
Biozol Catalog Number:
ABS-NKA-H5244-1MG
Supplier Catalog Number:
NKA-H5244-1mg
Alternative Catalog Number:
ABS-NKA-H5244-1MG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Unconjugated
NKG2A/CD159a is a transmembrane protein belonging to the CD94/NKG2 family of Ctype lectinlike receptors that inhibits innate immune system activation, also known as KLRC1, CD159a, NK cell receptor A and NKG2A/NKG2B type II integral membrane protein. NKG2A marks a unique immune effector subset preferentially coexpressing the tissueresident CD103 molecule, but not immune checkpoint inhibitors. NKG2A blockade therapy operated through CD8 T cells, but not NK cells. The increase in NKG2A expression might be induced by IL10, which was present at a high level in the plasma of HCC patients. Blocking IL10 could specifically inhibit NKG2A expression in NK cells. These findings indicate that NKG2A expression is influenced by factors from cancer nests and contributes to NK cell exhaustion, suggesting that NKG2A blockade has the potential to restore immunity against liver tumors by reversing NK cell exhaustion. - Proteine/Peptide
Human NKG2A, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
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