Human NOTCH2 Protein, Fc Tag (MALS verified), Unconjugated

Product Overview

• Article Name: Human NOTCH2 Protein, Fc Tag (MALS verified), Unconjugated
• Biozol Catalog Number: ABS-NO2-H5255-1MG
• Supplier Catalog Number: NO2-H5255-1mg
• Alternative Catalog Number: ABS-NO2-H5255-1MG
• Manufacturer: AcroBiosystems
• Host: Human
• Category: Proteine/Peptide
• Species Reactivity: Human
• Conjugation: Unconjugated

Product Description

Functions as a receptor for membranebound ligands Jagged1 (JAG1), Jagged2 (JAG2) and Delta1 (DLL1) to regulate cellfate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus . Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKLinduced osteoclast differentiation . Positively regulates selfrenewal of liver cancer cells . - Proteine/Peptide

Product Properties

• Molecular Weight: 80.5 kDa
• Tag: C-Fc
• NCBI: 04721
• Buffer: PBS, pH7.4
• Purity: 95%
• Form: Powder
• Target: NOTCH2

Images

NO2-H5255-1mg

Immobilized Human DLL4, His Tag (Cat. No. DL4-H5227) at 5 µg/mL (100 µL/well) can bind Human NOTCH2, Fc Tag (Cat. No. NO2-H5255) with a linear range of 5-78 ng/mL (QC tested).

Immobilized Human NOTCH2, Fc Tag (Cat. No. NO2-H5255) at 1 µg/mL (100 µL/well) can bind Bispecific Antibody (NOTCH2 * NOTCH3) with a linear range of 1-20 ng/mL (Routinely tested).

Human NOTCH2, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.