Human Niemann-Pick Type C2 / NPC2 Protein, His Tag, Unconjugated

Product Overview

• Article Name: Human Niemann-Pick Type C2 / NPC2 Protein, His Tag, Unconjugated
• Biozol Catalog Number: ABS-NP2-H52H1-1MG
• Supplier Catalog Number: NP2-H52H1-1mg
• Alternative Catalog Number: ABS-NP2-H52H1-1MG
• Manufacturer: AcroBiosystems
• Host: Human
• Category: Proteine/Peptide
• Species Reactivity: Human
• Conjugation: Unconjugated

Product Description

NiemannPick disease type C2 protein (NPC2) is also known as epididymal secretory protein E1 and human epididymisspecific protein 1 (HE1). NPC2 is a intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular tag team duo (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. Also,NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterolbinding pocket of the Nterminal domain of NPC1. Furthermore,the secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8mediated cholesterol transport. - Proteine/Peptide

Product Properties

• Molecular Weight: 16.5 kDa
• Tag: C-10*His
• NCBI: 61916
• Buffer: PBS, pH7.4
• Purity: 95%
• Form: Powder
• Target: Niemann-Pick Type C2

Images

Human NPC2, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.