Human OSCAR / PIgR-3 Protein, His Tag (MALS verified), Unconjugated
Biozol Catalog Number:
ABS-OSR-H52H3-1MG
Supplier Catalog Number:
OSR-H52H3-1mg
Alternative Catalog Number:
ABS-OSR-H52H3-1MG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Unconjugated
OSCAR (Osteoclastassociated immunoglobulinlike receptor), also known as PIgR3 (polymeric immunoglobulinlike receptor), is a type I transmembrane protein of the leukocyte receptor complex (LRC) family. OSCAR is specifically expressed by preosteoclasts and signals via FcR gamma. OSCAR costimulates one of the major FcR gamma associated pathways required for osteoclastogenesis in vivo. Collagen type I and collagen type II serve as ligands for OSCAR. OSCAR binds to specific motifs within fibrillary collagens in the extracellular matrix (ECM). OSCAR promoted osteoclastogenesis in vivo, and its binding to the collagen motif led to signaling that increased numbers of osteoclasts in culture. OSCAR contains two immunoglobulinlike domains, D1 and D2. Direct binding assays on OSCAR molecules showed that D2, but not D1, is critical for collagen binding. OSCAR may contribute to the pathogenesis and severity of a number of diseases including osteoporosis, atherosclerosis, chronic obstructive pulmonary disease and rheumatoid arthritis. - Proteine/Peptide
Immobilized Native Human Collagen I protein at 2 µg/mL (100 µL/well) can bind Human OSCAR, His Tag (Cat. No. OSR-H52H3) with a linear range of 0.039-1.25 µg/mL (QC tested).
Human OSCAR, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
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