Monoclonal Anti-Payload PBD Antibody, Rabbit IgG (1M1F9), Unconjugated, Human

Product Overview

• Article Name: Monoclonal Anti-Payload PBD Antibody, Rabbit IgG (1M1F9), Unconjugated, Human
• Biozol Catalog Number: ABS-PAD-MY2212-100UG
• Supplier Catalog Number: PAD-MY2212-100ug
• Alternative Catalog Number: ABS-PAD-MY2212-100UG
• Manufacturer: AcroBiosystems
• Host: Human
• Category: Antikörper
• Species Reactivity: Rabbit
• Conjugation: Unconjugated

Product Description

Pyrrolobenzodiazepine (PBD) dimer, is a new generation of cytotoxic payload used in antibodydrug conjugates (ADCs). The PBD dimer binds to the minor groove of DNA to form effective cytotoxic DNA interstrand crosslinks, which can block cell division and kill cancer cells. This mechanism of action utilizes a completely different cellular target from that of tubulin inhibitors, as well as a different DNA damage pattern from other DNAtargeting payloads. AntiPBD antibody is a rabbit monoclonal antibody specially reacts with PBD, which is more sensitive than mouse antibody. The antiPBD antibody is a useful reagent in PK assay to determine conjugated antibodies. - Antikörper

Product Properties

• Tag: Rabbit IgG | Rabbit Kappa
• Buffer: PBS, pH7.4
• Form: Powder
• Target: PBD

Images

Immobilized Monoclonal Anti-Payload PBD Antibody, Rabbit IgG (1M1F9) (Cat. No. PAD-MY2212) at 1 µg/mL, add Loncastuximab Tesirine in the 100% Human Serum and then add Biotinylated Human CD19 (20-291), His,Avitag, premium grade (Cat. No. CD9-H82E9) at 0.5 µg/mL. Detection was performed using HRP-conjugated Streptavidin (Acro, Cat. No. STN-NH913) (QC tested).

Serial dilutions of (PBD)SG3199 were added into Monoclonal Anti-Payload PBD Antibody, Rabbit IgG (1M1F9) (Cat. No. PAD-MY2212)): Loncastuximab Tesirine binding reactions. The half maximal inhibitory concentration (IC50) is 0.02167 µg/mL (Routinely tested).