Biotinylated Monoclonal Anti-PBD Antibody, Rabbit IgG (1M1F9), Human
Biozol Catalog Number:
ABS-PBD-BLMY2212-100UG
Supplier Catalog Number:
PBD-BLMY2212-100ug
Alternative Catalog Number:
ABS-PBD-BLMY2212-100UG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Antikörper
Species Reactivity:
Rabbit
Conjugation:
Biotin
Pyrrolobenzodiazepine (PBD) dimer, is a new generation of cytotoxic payload used in antibodydrug conjugates (ADCs). The PBD dimer binds to the minor groove of DNA to form effective cytotoxic DNA interstrand crosslinks, which can block cell division and kill cancer cells. This mechanism of action utilizes a completely different cellular target from that of tubulin inhibitors, as well as a different DNA damage pattern from other DNAtargeting payloads. AntiPBD antibody is a rabbit monoclonal antibody specially reacts with PBD, which is more sensitive than mouse antibody. The antiPBD antibody is a useful reagent in PK assay to determine conjugated antibodies. - Antikörper
Tag:
Rabbit IgG | Rabbit Kappa
Buffer:
PBS, pH7.4
Form:
Powder
Target:
PBD
Immobilized Human CD19 (20-291), His Tag (Cat. No. CD9-H52H2) at 5 µg/mL, add Loncastuximab tesirine in the 100% Human Serum and then add Biotinylated Monoclonal Anti-PBD Antibody, Rabbit IgG (1M1F9) (Cat. No. PBD-BLMY2212) at 0.5 µg/mL. Detection was performed using HRP-conjugated Streptavidin (Acro, Cat. No. STN-NH913) (QC tested).
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