HRP conjugated Monoclonal Anti-PBD Antibody, Rabbit IgG (M1D08), Human

Product Overview

• Article Name: HRP conjugated Monoclonal Anti-PBD Antibody, Rabbit IgG (M1D08), Human
• Biozol Catalog Number: ABS-PBD-PLMY2221-100UG
• Supplier Catalog Number: PBD-PLMY2221-100ug
• Alternative Catalog Number: ABS-PBD-PLMY2221-100UG
• Manufacturer: AcroBiosystems
• Host: Human
• Category: Antikörper
• Species Reactivity: Rabbit
• Conjugation: HRP

Product Description

Pyrrolobenzodiazepine (PBD) dimer, is a new generation of cytotoxic payload used in antibodydrug conjugates (ADCs). The PBD dimer binds to the minor groove of DNA to form effective cytotoxic DNA interstrand crosslinks, which can block cell division and kill cancer cells. This mechanism of action utilizes a completely different cellular target from that of tubulin inhibitors, as well as a different DNA damage pattern from other DNAtargeting payloads. AntiPBD antibody is a rabbit monoclonal antibody specially reacts with PBD, which is more sensitive than mouse antibody. The antiPBD antibody is a useful reagent in PK assay to determine conjugated antibodies. - Antikörper

Product Properties

• Tag: Rabbit IgG | Rabbit Kappa
• Buffer: PBS, pH7.4
• Form: Powder
• Target: PBD

Images

Immobilized Human CD19 (20-291), Fc Tag, premium grade (Cat. No. CD9-H5251) at 5 µg/mL, add Loncastuximab tesirine and then add HRP conjugated Monoclonal Anti-PBD Antibody, Rabbit IgG (M1D08) (Cat. No. PBD-PLMY2221) at 0.5 µg/mL (QC tested).