Proprotein convertase subtilisin/kexin type 9 (PCSK9) is also known as NARC1 (neural apoptosis regulated convertase), is a newly identified subtilase belonging to the peptidase S8 subfamily. Mouse PCSK9 is synthesized as a soluble zymogen, and undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted active enzyme with a broad alkaline pH optimum. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factorlike repeat A (EGFA) domain of the lowdensity lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3). - Proteine/Peptide
Immobilized Human VLDL R, His Tag (Cat. No. VLR-H5227) at 5 µg/mL (100 µL/well) can bind Human PCSK9, Fc Tag (Cat. No. PC9-H5256) with a linear range of 1-10 ng/mL (QC tested).
Immobilized Human PCSK9, Fc Tag (Cat. No. PC9-H5256) at 5 µg/mL (100 µL/well) can bind Biotinylated Human LDL R, His Tag, Avi Tag (Cat. No. LDR-H82E7) with a linear range of 0.04-0.625 µg/mL (Routinely tested).
Human PCSK9, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
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