Proprotein convertase subtilisin/kexin type 9 (PCSK9) is also known as NARC1 (neural apoptosis regulated convertase), is a newly identified subtilase belonging to the peptidase S8 subfamily. Mouse PCSK9 is synthesized as a soluble zymogen, and undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted active enzyme with a broad alkaline pH optimum. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factorlike repeat A (EGFA) domain of the lowdensity lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3). - Proteine/Peptide
Immobilized Mouse PCSK9, His Tag (Cat. No. PC9-M5228) at 5 µg/mL (100 µL/well) can bind Human LDL R, Fc Tag (Cat. No. LDR-H5251) with a linear range of 0.3-10 ng/mL (QC tested).
Immobilized Mouse PCSK9, His Tag (Cat. No. PC9-M5228) at 1 µg/mL (100 µL/well) on Monoclonal Anti-His Tag Antibody, Mouse IgG1 (AY63) precoated (0.1 µg/well) plate can bind Evolocumab with a linear range of 2-31 ng/mL (Routinely tested).
PC9-M5228-1mg
Mouse PCSK9, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
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