Human PD-L2 / B7-DC Protein, Mouse IgG1 Fc Tag, Unconjugated

Product Overview

• Article Name: Human PD-L2 / B7-DC Protein, Mouse IgG1 Fc Tag, Unconjugated
• Biozol Catalog Number: ABS-PD2-H52A5-100UG
• Supplier Catalog Number: PD2-H52A5-100ug
• Alternative Catalog Number: ABS-PD2-H52A5-100UG
• Manufacturer: AcroBiosystems
• Host: Human
• Category: Proteine/Peptide
• Species Reactivity: Human
• Conjugation: Unconjugated

Product Description

Programmed cell death 1 ligand 2 (PDL2 or PDCD1 ligand 2) is also known as Butyrophilin B7DC, CD antigen CD273, which belongs to the immunoglobulin superfamily or BTN/MOG family. The expression of PDL2 is upregulated by IFNG/IFNgamma stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with CSF2 and IL4. PDL2 Involved in the costimulatory signal, essential for Tcell proliferation and IFNG production in a PDCD1independent manner. PDL2 interaction with PDCD1 inhibits Tcell proliferation by blocking cell cycle progression and cytokine production. - Proteine/Peptide

Product Properties

• Molecular Weight: 48.9 kDa
• Tag: C-mFc(mIgG1)
• NCBI: 13679
• Buffer: Tris with Glycine, Arginine and NaCl, pH7.5
• Purity: 95%
• Form: Powder
• Target: PD-L2

Images

Immobilized Human PD-1, His Tag (Cat. No. PD1-H5221) at 2 µg/mL (100 µL/well) can bind Human PD-L2, Mouse IgG1 Fc Tag (Cat. No. PD2-H52A5) with a linear range of 10-156 ng/mL (QC tested).

Serial dilutions of nivolumab were added into Human PD-L2, Mouse IgG1 Fc Tag (Cat. No. PD2-H52A5): Biotinylated Human PD-1, Fc,Avitag (Cat. No. PD1-H82F1) binding reactions. The half maximal inhibitory concentration (IC50) is 0.2823 µg/mL (Routinely tested).

PD2-H52A5-100ug

Human PD-L2, Mouse IgG1 Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.