Human PDGF-BB Protein, premium grade, Unconjugated, E. coli
Biozol Catalog Number:
ABS-PDB-H4112-20UG
Supplier Catalog Number:
PDB-H4112-20ug
Alternative Catalog Number:
ABS-PDB-H4112-20UG
Manufacturer:
AcroBiosystems
Host:
E. coli
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Unconjugated
PDGFs are mitogenic during early developmental stages, driving the proliferation of undifferentiated mesenchyme and some progenitor populations. During later maturation stages, PDGF signalling has been implicated in tissue remodelling and cellular differentiation, and in inductive events involved in patterning and morphogenesis. In addition to driving mesenchymal proliferation, PDGFs have been shown to direct the migration, differentiation and function of a variety of specialised mesenchymal and migratory cell types, both during development and in the adult animal. Other growth factors in this family include vascular endothelial growth factors B and C (VEGFB, VEGFC)which are active in angiogenesis and endothelial cell growth, and placenta growth factor (PlGF) which is also active in angiogenesis. PDGF plays a role in embryonic development, cell proliferation, cell migration, and angiogenesis. PDGF is a required element in cellular division for fibroblast, a type of connective tissue cell. PDGF is also known to maintain proliferation of oligodendrocyte progenitor cells. Plateletderived growth factor subunit B is also known as PDGFB, FLJ12858, PDGF2, SIS, SSV, csis, is a member of the plateletderived growth factor family. PDGFB can exist either as a homodimer (PDGFBB) or as a heterodimer with the plateletderived growth factor alpha polypeptide (PDGFAB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. - Proteine/Peptide
Immobilized Human PDGF-BB, premium grade (Cat. No. PDB-H4112) at 1 µg/mL (100 µL/well) can bind Human PDGF R beta, Fc Tag (Cat. No. PDB-H5259) with a linear range of 1-39 ng/mL (QC tested).
Human PDGF-BB, premium grade on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
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