Human PDGF R beta / CD140b Protein, Fc Tag, Unconjugated
Biozol Catalog Number:
ABS-PDB-H5259-100UG
Supplier Catalog Number:
PDB-H5259-100ug
Alternative Catalog Number:
ABS-PDB-H5259-100UG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Human
Conjugation:
Unconjugated
Human plateletderived growth factor receptor, beta polypeptide (PDGFRB) is also called J03278, M21616, CD140B, JTK12, PDGFRbeta and PDGFR, is receptor that binds specifically to PDGFB and has a tyrosineprotein kinase activity. Is a cell surface tyrosine kinase receptor for members of the plateletderived growth factor (PDGF) family. The PDGFR/PDGF system includes two receptors (PDGFRA and PDGFRB) and four ligands (A, B, C and D). The receptors PDGFRA and PDGFRB are related in sequence and both are members of the class III subtype of receptor tyrosine kinases (RTKs). Other class III RTKs are CSF1R, KIT and FLT3. PDGF binding induces receptor homo and heterodimerization and signal transduction. The expression of the alpha and beta receptors is independently regulated in various cell types. Recombinant soluble PDGFRB binds PDGF with high affinity and is potent PDGF antagonist. The ligands form either homo or heterodimers (PDGFAA, AB, BB, CC, DD). The four PDGFs are inactive in their monomeric forms. The PDGFs bind to the protein tyrosine kinase receptors PDGF receptoralpha and beta. These two receptor isoforms dimerize upon binding the PDGF dimer, leading to three possible receptor combinations, namely alphaalpha, betabeta and alphabeta. PDGFCC specifically interacts with PDGFRalphaalpha and alphabeta, but not with -betabeta, and thereby resembles PDGFAB. PDGFDD binds to PDGFRbetabeta with high affinity, and to PDGFRalphabeta to a much lower extent and is regarded as PDGFRbetabeta specific. PDGFAA binds only to PDGFRalphaalpha, while PDGFBB is the only PDGF that can bind all three receptor combinations with high affinity. - Proteine/Peptide
Immobilized Human PDGF-BB, premium grade (Cat. No. PDB-H4112) at 1 µg/mL (100 µL/well) can bind Human PDGF R beta, Fc Tag (Cat. No. PDB-H5259) with a linear range of 0.6-10 ng/mL (QC tested).
Human PDGF R beta, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
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