HPV18 E6 Protein, Twin-Strep Tag,MBP,His Tag, Unconjugated, E. coli
Biozol Catalog Number:
ABS-PE6-V5143-100UG
Supplier Catalog Number:
PE6-V5143-100ug
Alternative Catalog Number:
ABS-PE6-V5143-100UG
Manufacturer:
AcroBiosystems
Host:
E. coli
Category:
Proteine/Peptide
Species Reactivity:
Virus
Conjugation:
Unconjugated
Human papillomavirus (HPV) E6 and E7 viral oncoproteins play the pivotal role in driving the cells toward oncogenesis. In their process of replicating the viral genome, they can induce all the hallmarks of a cancer cell, i.e., uncontrolled cellular proliferation, angiogenesis, invasion, metastasis, and unrestricted telomerase activity along with the evasion of apoptosis and growth suppressors activity. E6 associates with host UBE3A/E6AP ubiquitinprotein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation. The complex E6/E6AP targets several other substrates to degradation via the proteasome including host DLG1 or NFX1, a repressor of human telomerase reverse transcriptase (hTERT). The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization. Other cellular targets including BAK1, Fasassociated death domaincontaining protein (FADD) and procaspase 8, are degraded by E6/E6AP causing inhibition of apoptosis. E6 also inhibits immune response by interacting with host IRF3 and TYK2. These interactions prevent IRF3 transcriptional activities and inhibit TYK2mediated JAKSTAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway. - Proteine/Peptide
