Plexin B2 serves as the receptor of Sema4C and Sema4G. By signaling the effect of Sema4C and Sema4G, the plexin B2 receptor plays important roles in neural tube closure and cerebellar granule cell development. Mice lacking Plexin B2 demonstrated defects in closure of the neural tube and disorganization of the embryonic brain. In developing kidney, Sema4CPlexin B2 signaling modulates ureteric branching. Plexin B2 is expressed both in the pretubular aggregates and the ureteric epithelium in the developing kidney. Deletion of Plexin B2 results in renal hypoplasia and occasional double ureters. The Sema domain is located at the Nterminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligandrecognition and binding module. - Proteine/Peptide
Immobilized Human Plexin B2, His Tag (Cat. No. PL2-H52H3) at 5 µg/mL (100 µL/well) can bind Human SEMA4D, Fc Tag (Cat. No. CD0-H5257) with a linear range of 0.039-1.25 µg/mL (QC tested).
Human Plexin B2, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
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