Monoclonal Anti-PNU-159682 Antibody, Rabbit IgG (P1C01), Unconjugated, Human
Biozol Catalog Number:
ABS-PNU-MY2371-1MG
Supplier Catalog Number:
PNU-MY2371-1mg
Alternative Catalog Number:
ABS-PNU-MY2371-1MG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Antikörper
Species Reactivity:
Rabbit
Conjugation:
Unconjugated
PNU159682 is a topoisomerase II inhibitor serving as a payload for antibodydrug conjugates (ADCs). Its mechanism of action involves stabilizing the complex formed by topoisomerase II and DNA, blocking DNA repair and replication processes, and thereby inducing cancer cell apoptosis. Some ADCs containing PNU159682 have entered the preclinical research stage, showing targeted killing activity in solid tumor models, with particularly significant effects on tumors with high topoisomerase II expression. - Antikörper
Tag:
Rabbit IgG | Rabbit Kappa
Buffer:
PBS, pH7.4
Form:
Powder
Target:
PNU-159682
Immobilized Monoclonal Anti-PNU-159682 Antibody, Rabbit IgG (P1C01) (Cat. No. PNU-MY2371) at 1 µg/mL (100 µL/well) can bind ADC-PNU-159682 with a linear range of 1-31 ng/mL (QC tested).
Serial dilutions of PNU-159682 were added into Monoclonal Anti-PNU-159682 Antibody, Rabbit IgG (P1C01) (Cat. No. PNU-MY2371): Human IgG1 Kappa Isotype Control (mAb) (Cat. No. DNP-M2) binding reactions. The half maximal inhibitory concentration (IC50) is 1.95 ng/mL (Routinely tested).
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