Human Nectin-3 / CD113 Protein, Fc Tag, Unconjugated

Product Overview

• Article Name: Human Nectin-3 / CD113 Protein, Fc Tag, Unconjugated
• Biozol Catalog Number: ABS-PV3-H5255-1MG
• Supplier Catalog Number: PV3-H5255-1mg
• Alternative Catalog Number: ABS-PV3-H5255-1MG
• Manufacturer: AcroBiosystems
• Host: Human
• Category: Proteine/Peptide
• Species Reactivity: Human
• Conjugation: Unconjugated

Product Description

Poliovirus receptorrelated 3 (PVRL3), also known as nectin3 and CD113, is a human protein of the immunoglobulin superfamily which forms part of adherens junctions. Nectins are immunoglobulinlike adhesion molecules that interact with afadin (AF6, MIM 159559). Afadin is an actin filamentbinding protein that connects nectins to the actin cytoskeleton. The nectinafadin system organizes adherens junctions cooperatively with the cadherin system in epithelial cells. PVRL3 plays a role in cellcell adhesion through heterophilic transinteractions with nectinlike proteins or nectins, such as transinteraction with PVRL2/nectin2 at Sertolispermatid junctions. Furthermore, PVRL3 induces endocytosismediated downregulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. - Proteine/Peptide

Product Properties

• Molecular Weight: 64.3 kDa
• Tag: C-Fc
• NCBI: 9
• Buffer: Tris with Glycine, Arginine and NaCl, pH7.5
• Purity: 95%
• Form: Powder
• Target: Nectin-3

Images

PV3-H5255-1mg

Immobilized Human Nectin-1, His Tag (Cat. No. PV1-H5223) at 2 µg/mL (100 µL/well) can bind Human Nectin-3, Fc Tag (Cat. No. PV3-H5255) with a linear range of 5-78 ng/mL (QC tested).

Immobilized Human TIGIT, His Tag (Cat. No. TIT-H52H5) at 1 µg/mL (100 µL/well) can bind Human Nectin-3, Fc Tag (Cat. No. PV3-H5255) with a linear range of 0.078-5 µg/mL (Routinely tested).

Human Nectin-3, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.