Biotinylated Mouse ROR1 Protein, Fc,Avitag(TM) (MALS verified), Human
Biozol Catalog Number:
ABS-RO1-M82F3-25UG
Supplier Catalog Number:
RO1-M82F3-25ug
Alternative Catalog Number:
ABS-RO1-M82F3-25UG
Manufacturer:
AcroBiosystems
Host:
Human
Category:
Proteine/Peptide
Species Reactivity:
Mouse
Conjugation:
Biotin
Tyrosineprotein kinase transmembrane receptor ROR1 is also known as Neurotrophic tyrosine kinase, receptorrelated 1 (NTRKR1), which belongs to the protein kinase superfamily or tyr protein kinase family or ROR subfamily. ROR1 contains 1 FZ (frizzled) domain, 1 Iglike C2type (immunoglobulinlike) domain, 1 kringle domain, 1 protein kinase domain. ROR1 is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. ROR1 could interact with casein kinase 1 epsilon (CK1epsilon) to activate phosphoinositide 3kinasemediated AKT phosphorylation and cAMPresponseelementbinding protein (CREB), which was associated with enhanced tumorcell growth. - Proteine/Peptide
